Currently available OIE-approved International Standard Sera

OIE-approved International Standard Sera

The OIE Biological Standards Commission (Laboratories Commission) coordinates a programme for the preparation, validation and distribution of OIE-approved International Reference Standards for antibody assays for infectious diseases of animals. The standards are prepared by an OIE Reference Laboratory in accordance with Guidelines drawn-up by the Laboratories Commission and in collaboration with other laboratories. Such standard preparations are designated by the OIE as primary reference standards for use in conjunction with tests described in the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Aniamls (mammals, birds and bees). The aim of the programme is to harmonise diagnostic testing and encourage the mutual recognition of test results for international trade.

Disease	Test	Available from
African horse sickness	Enzyme-linked immunosorbent assay	Marisa Arias Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentarie (CISA-INIA), 28130 Valdeolmos, Madrid, Spain Tel: (34.91) 620.23.00; Fax: (34.91) 620.22.47; arias@inia.es
Aujeszky's disease	Enzyme-linked immunosorbent assay; Virus neutralisation	Services des Maladies Contagieuses, Ecole Nationale Vétérinaire d'Alfort, 7 avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex, France Tel: 33 (0)1 43.96.71.00; Fax: 33 (0)1 43.96.71.25; communication@vet-alfort.fr direction@vet-alfort.fr
Contagious bovine pleuropneumonia	Both irradiated and non-irradiated sera are availalbe. Please contact the Reference Laboratory (Dr Pini) for advice on their suitability for different types of serological test (complement fixation test, indirect or competitive enzyme-linked immunosorbent assay)	Dr A. Pini CESME, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Via Campo Boario, 64100 Teramo, Italy Tel: (39.0861) 33.22.28 Fax: (39.0861) 33.22.51 a.pini@izs.it
Equine infectious anaemia	Agar gel immunodiffusion	Dr S. Zientara UMR 1161 Virologie Afssa/INRA/ENVA, 23 avenue du Général de Gaulle, 94703 Maisosn-Alfort, France Tel: 33 (0)1 43.96.71.00; Fax: 33 (0)1 43.96.71.25; szientara@vet-alfort.fr
Bluetongue	Enzyme-linked immunosorbent assay; Agar gel immunodiffusion	Dr E.N. Ostlund National Veterinary Services Laboratories, Animal & Plant Health Inspection Service, USDA, P.O. Box 844, Ames, Iowa 50010, United States of America Tel: (1.515) 663.75.51; Fax: (1.515) 663.73.48; eileen.n.ostlund@aphis.usda.gov
Bovine brucellosis	Indirect enzyme-linked immunosorbent assay; Buffered Brucella antigen test	Mrs J.A. Stack VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom Tel: (44.1932) 34.11.11; Fax: (44.1932) 34.70.46; j.a.stack@vla.defra.gsi.gov.uk
Brucella abortus	Complement fixation; Agglutination; Buffered Brucella antigen test	Mrs J.A. Stack (as above)
anti-Brucella melitensis ( ISaBmS)	Competitive enzyme-linked immunosorbent assay; Fluorescence polarisation assay	Mrs J.A. Stack (as above)
Brucella ovis	Complement fixation	Mrs J.A. Stack (as above)
Classical swine fever	Virus neutralisation	Dr T.W. Drew VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom Tel: (44.1932) 34.11.11; Fax: (44.1932) 34.70.46; t.w.drew@vla.defra.gsi.gov.uk
Enzootic bovine leukosis	Agar gel immunodiffusion	Dr T. Vahlenkamp Friedrich-Loeffler-Institute, Südufer 10; 17493 Greifswald-Insel Riems, GERMANY Tel: ( +4-38351) 7172; Fax: ( +49-38351) 7151; thomas.vahlenkamp@fli.bund.de
Enzootic bovine leukosis	Enzyme-linked immunosorbent assay	Dr T.W. Drew VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom Tel: (44.1932) 34.11.11; Fax: (44.1932) 34.70.46; t.w.drew@vla.defra.gsi.gov.uk
Equine influenza	Haemagglutination inhibition; single radial haemolysis	Dr Marie-Emmanuelle Behr-Gross European Directorate for the Quality of Medicines, Council of Europe, 224 avenue de Colmar (entrée rue Schertz), F-67100 Strasbourg, France Tel: 33 (0)3 90.21.41.08; Fax: 33(0)3. 88.41.27.71; marie-emmanuelle.behr-gross@pheur.org
Equine influenza	Antigens and antisera for in-vitro standardisation of vaccines	NIBSC (National Institute for Biological Standards and Control), P.O. Box 1193, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QH, United Kingdom Tel: (44.1707) 65.47.53; Fax: (44.1707) 64.67.30; standards@nibsc.ac.uk
Equine viral arteritis	Virus neutralisation	Dr P.J. Timoney Maxwell H. Gluck Equine Research Center, Dept of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546-0099, United States of America Tel: (1.859) 257.15.31; Fax: (1.859) 257.85.42; ptimoney@uky.edu
Foot and mouth disease	Enzyme-linked immunosorbent assay (antigen detection); Virus neutralisation	Dr J. Hammond Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, United Kingdom Tel: (44-1483) 23.24.41; Fax: (44-1483) 23.24.48; jef.hammond@bbsrc.ac.uk
Foot and mouth disease)	Nonstructural protein tests	Dr Rossana Allende Centro Panamericano de Fiebre Aftosa OPS/OMS Av. President Kennedy 7778, Sao Bento, Duque de Caxias, ZC 20054-40 Rio de Janeiro, Brazil Tel: (55.21) 36.61.90.64; Fax: (55.21) 36.61.90.01 ; rallende@panaftosa.ops-oms.org
Infectious bovine rhinotracheitis	Virus neutralisation; Enzyme-linked immunosorbent assay	Dr J.A. Kramps Central Veterinary Institute of Wageningen UR, Division of Virology, Section Diagnostics, Supervision and Crisis Organisation, P.O. Box 65, 8200 AB Lelystad, The Netherlands Tel: (31.320) 23.82.17; Fax: (31.320) 23.86.68; hans.kramps@wur.nl Dr E. Dubois AFSSA Sophia-Antipolis, Laboratoire d'Etudes et de Recherches sur les Ruminants et les Abeilles, 105 routes des Chappes, B.P. 111, 06902 SOPHIA-ANTIPOLIS, France Tel: 33 (0)4 92.94.37.00; Fax : 33 (0)4 92.94.37.01; eric.dubois@anses.fr
Peste des petits ruminants	Enzyme-linked immunosorbent assay	Dr G. Libeau CIRAD/EMVT, Campus international de Baillarguet, Montferriez-sur-Lez, B.P. 5035, 34032 Montpellier Cedex 01, France Tel: 33 (0)4 67.59.37.11; Fax: 33 (0)4 67.59.37.98; genevieve.libeau@cirad.fr
Rabies	Fluorescent antibody virus neutralisation	Dr F. Cliquet AFSSA Nancy, Laboratoire d'études sur la rage et la pathologie des animaux sauvages, Domaine de Pixérécourt, BP 9, 54220 Malzéville, France Tel: 33 (0)3 83.29.89.50; Fax: 33 (0)3 83.29.89.58; florence.cliquet@anses.fr
Rinderpest	Enzyme-linked immunosorbent assay	Dr C. Oura Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, United Kingdom Tel: (44.1483) 23.24.41; Fax (44.1483) 23.24.48; chris.oura@bbsrc.ac.uk

The term 'International Standard Serum' is synonymous with primary standard. It represents the standard serum by which all others (secondary standards) are compared and calibrated. Secondary standards may represent national standards or working standards that are in routine use at the diagnostic laboratory level. The secondary standard and not the International Standard are to be used on a daily basis to standardise testing. The International Standard Sera listed above may be obtained, in small quantities, at the corresponding address. Some laboratories may make a charge for this service.