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Product title :

Influenza receptors, polymerase and host range

Author(s) : M. Matrosovich, J. Stech & H. Dieter Klenk

Summary :

Influenza infection is initiated by virus attachment to sialic acid-containing cellsurface receptors. The spectrum of sialylglycoconjugates varies substantially between viral host species as well as target tissues and cell types of the same species, leading to variations in the receptor-binding specificity of viruses circulating in these hosts. Therefore, receptor specificity plays an important role in the viral cell and tissue tropism, interspecies transmission and adaptation to a new host, and a poor fit of avian viruses to receptors in humans limits the emergence of new pandemic strains.
 
Keywords
Evolution – HPAIV – Host factors – Host range – Influenza A virus – Pandemic – Polymerase – Receptor specificity.

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