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|Author(s) :||P.C. Doherty, L.E. Brown, A. Kelso & P.G. Thomas|
While the basic principles of immunity to the influenza A viruses are probably similar for all vertebrates, detailed understanding is based largely on experiments in laboratory mice. Elements of the innate response limit early virus replication, although high pathogenicity strains can trigger effusive cytokine/chemokine production and lethal shock. Virus clearance is normally mediated via CD8+ effector T cells but, in their absence, the class-switched antibody response can ultimately achieve the same goal.
Antibody – Cytokine shock – Cytotoxicity – Memory – Protection – Secondary response – T-cell.