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Product title :

Bioinformatics tools for analysing viral genomic data

Author(s) : R.J. Orton, Q. Gu, J. Hughes, M. Maabar, S. Modha, S.B. Vattipally, G.S. Wilkie & A.J. Davison

Summary :

The field of viral genomics and bioinformatics is experiencing a strong resurgence due to high-throughput sequencing (HTS) technology, which enables the rapid and cost-effective sequencing and subsequent assembly of large numbers of viral genomes. In addition, the unprecedented power of HTS technologies has enabled the analysis of intra-host viral diversity and quasispecies dynamics in relation to important biological questions on viral transmission, vaccine resistance and host jumping. HTS also enables the rapid identification of both known and potentially new viruses from field and clinical samples, thus adding new tools to the fields of viral discovery and metagenomics. Bioinformatics has been central to the rise of HTS applications because new algorithms and software tools are continually needed to process and analyse the large, complex datasets generated in this rapidly evolving area.

Keywords
Bioinformatics – De novo assembly – High-throughput sequencing – Metagenomics – Next-generation sequencing – Quasispecies – Software – Variant calling – Virus.

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