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Product title :

Development and evaluation of a live attenuated camelpox vaccine from a local field isolate of the virus

Author(s) : M.M. Abdellatif, A.A. Ibrahim & A.I. Khalafalla

Summary :

No. 06102014-00043-EN

A strain of camelpox virus (CMLV) isolated in the Sudan was attenuated by serial passage in Vero cell monolayers for use as a future vaccine strain. The safety and potency of passage 115 virus (designated Sudan CMLV/115) was tested. Camels inoculated with CMLV/115 showed no clinical disease or skin lesions, developed low-level antibodies and cell-mediated immune response and resisted challenge with virulent wild-type CMLV. Field testing of the candidate vaccine showed that the developed vaccine induces immune response and is safe for young and pregnant camels.

Keywords
Camelpox – Camelpox virus – Cell culture attenuation – Vaccine – Vaccine evaluation.

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