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Product title :

Evaluation of the safety of live attenuated vaccine viruses against infectious bursal disease (Gumboro disease) in conventional broiler chicks

Author(s) : A. Boudaoud & N. Alloui

Summary :

The pathological and immunological effects of two infectious bursal disease (Gumboro disease) vaccines containing attenuated virus were evaluated under experimental conditions. A total of 200 conventional broiler chicks were divided into three batches, two of which were administered an experimental dose of Gumboro disease vaccine via the ocular route, at 14 days of age, using an ‘intermediate’ strain for one group and an ‘intermediate plus’ strain for the other. At different post-inoculation intervals, the chicks from the three batches were weighed and slaughtered and their bursa of Fabricius were removed to be weighed and subjected to histological examination. This allowed a lesion score and a ratio between the weight of the bursa of Fabricius and body weight to be calculated for each group of chicks.
 
Keywords
Atrophy – Bursa of Fabricius – Gumboro disease – Immunosuppression – Infectious bursal disease – Pathogenicity – Safety – Vaccination.

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